A Review on the Therapeutic Potentials of Parthenolide: a Sesquiterpene Lactone
نویسندگان
چکیده
Medicinal plants have been widely employed in treating various diseases for centuries and are still a major resource and repository that can be further exploited for a variety of infectious and non-infectious ailments. The popularity of medicinal herbs has grown significantly in recent years despite a dearth of information regarding their modes of action and continuing concerns over their efficacy. Hence there is a necessity to study various plants meticulously with respect to their biological properties. Recent efforts to elucidate the mechanisms of action of several anti-inflammatory herbs have focused on a class of compounds, sesquiterpene lactones, which are believed to be the active components of these herbal medicines. At present, the pharmacokinetics of sesquiterpene lactones is not well known. Parthenolide is a major sesquiterpene lactone isolated from medical herbs Tanacetum parthenium (commonly known as feverfew) and from Magnolia grandiflora. Feverfew has been traditionally used as a herbal medicine for the treatment of fever, arthritis, and migraine in Asia and Europe for centuries. Hence, the present study discusses various biological properties of parthenolide and its mode of action which can be used in drug designing processes to maximize efficacy and minimize side-effects.
منابع مشابه
Anti-proliferative effect and apoptotic induction of sesquiterpene lactone parthenolide in a human breast cancer cell line
Parthenolide is a secondary metabolite, which naturally occurs in the feverfew plant and is responsible for its healing power. The potential of parthenolide in inhibition of cancer cell growth, alone or in combination with other anti-cancer therapeutics, have been studied in several laboratories. In this study, the effect of extracted parthenolide on the expression of seven pro-apoptotic genes,...
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Feverfew (Tanacetum parthenium) is a medicinal herb that has long enjoyed traditional use as a remedy for migraine headache pain. The aerial parts of Feverfew (flowers, leaves and stems) contain parthenolide (a sesquiterpene lactone) which is believed to be responsible for the plant's biological activity. Dried feverfew aerial parts should contain approximately 0.2-0.5 wt.% parthenolide and adu...
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